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Chloridite and amidite automated synthesis of oligodeoxyribonucleotides using amidine protected nucleosides
L Arnold1, Z Tocík, E Bradková
1Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.
Nucleic Acids Symposium Series
|January 1, 1987
Abstract:
Automated synthesis of oligodeoxyribonucleotides using in situ prepared methylchlorophosphite intermediates from amidine protected purine nucleosides is described. Phosphoramidite method using 1-methylimidazole trifluoromethanesulfonate as mediator is described.