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New approach to automated synthesis of oligoribonucleotides
H Schirmeister1, R Charubala, B S Schulz
1Fakultät für Chemie, Universität Konstanz, FRG.
Nucleic Acids Symposium Series
|January 1, 1987
Abstract:
The combination of 2'-OH protection in ribonucleosides by the p-nitrophenylethylsulfonyl (NPES) group with the 3'-(beta-cyanoethyl) (N,N-diisopropyl)-phosphoramidite function reveals a new approach to oligoribonucleotide synthesis. The corresponding adenosine and guanosine derivatives have been applied to automated solid phase synthesis with good success.