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Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans
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Exercise modifies fatty acid perception and metabolism.

Deepankumar Shanmugamprema1, Karthi Muthuswamy1, Vinithra Ponnusamy1

  • 1Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Marudhamalai Road, Coimbatore, Tamil Nadu, 641046, India.

Acta Physiologica (Oxford, England)
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Voluntary wheel running (VWR) in obese mice improved fat taste preference and metabolic health. Exercise-induced orosensory adaptations to long-chain fatty acids (LCFAs) were observed, highlighting VWR

Keywords:
CD36exercisefat tasteobesitytaste budstaste receptors

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Area of Science:

  • Neuroscience
  • Physiology
  • Public Health

Background:

  • Obesity is a significant global health concern linked to numerous chronic diseases.
  • Voluntary wheel running (VWR) in rodents impacts eating habits and metabolic processes.
  • Understanding exercise's role in modulating taste perception is crucial for obesity management.

Purpose of the Study:

  • To investigate how voluntary wheel running (VWR) affects fat taste perception in obese mice.
  • To determine if VWR can mitigate the immediate metabolic consequences of fatty acid (FA) consumption.
  • To explore the molecular mechanisms underlying VWR-induced changes in fat taste signaling.

Main Methods:

  • Male C57BL/6 mice were divided into sedentary (SED) and VWR groups after a 5-week diet.
  • Evaluated fat preference, glucose tolerance, and performed electrophysiological recordings in taste bud cells (TBCs).
  • Assessed gene expression of CD36 and GPR120 in TBCs, key players in fat taste perception.

Main Results:

  • VWR temporarily reduced body weight and improved glucose homeostasis in obese mice.
  • Enhanced preference scores for fatty acids (FAs) were observed in VWR-exercising obese mice.
  • Electrophysiology revealed altered calcium signaling in CD36-positive TBCs; gene expression differences in CD36 and GPR120 were noted between VWR and SED groups.

Conclusions:

  • VWR induces orosensory adaptations related to fat taste perception.
  • Exercise significantly alters taste preferences for long-chain fatty acids (LCFAs).
  • These findings suggest VWR as a potential strategy to modify dietary fat intake and improve metabolic health.