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Related Experiment Video

Updated: Aug 5, 2025

Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
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Post-hepatectomy liver failure: A timeline centered review.

Mohamed Bekheit1, Lisa Grundy2, Ahmed Ka Salih3

  • 1Department of Surgery, NHS Grampian, Foresterhill Health Campus, Ashgrove Road, AB252ZN Aberdeen, UK; Institute of Medical Sciences, Medical School, Foresterhill Health Campus, Ashgrove Road, AB252ZN Aberdeen, UK; Hépatica, Integrated Center of HPB Care, Elite Hospital, Agriculture Road, Alexandria, Egypt.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Preventing post-hepatectomy liver failure (PHLF) is crucial for patient survival. Remnant liver volume manipulation is the most effective strategy for preventing PHLF after liver surgery.

Keywords:
Liver neoplasmsManagementPost-hepatectomy liver failurePredictionPrevention

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Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Gastroenterology

Background:

  • Post-hepatectomy liver failure (PHLF) significantly contributes to mortality following liver surgery.
  • Understanding risk stratification and prevention is essential for improving patient outcomes.
  • This review focuses on preventive strategies for PHLF in the context of curative liver resections.

Approach:

  • Systematic review of 245 human and animal studies published between July 1997 and June 2020.
  • Literature search across major electronic databases (Cochrane Library, Embase, MEDLINE/PubMed, Web of Knowledge).
  • Quality assessment of included studies using Downs and Black's checklist; qualitative data synthesis.

Key Points:

  • Identifies current prediction, prevention, diagnosis, and management options for PHLF.
  • Liver volume manipulation is the most frequently studied preventive measure.
  • Modest improvements in PHLF treatment strategies observed over the last decade.

Conclusions:

  • Remnant liver volume manipulation emerges as the most consistent and effective preventive measure against PHLF.
  • Highlights the importance of proactive strategies in managing PHLF risk.