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Subcutaneous fat infiltration into the dermal layer induces wrinkle formation
1Shiseido Co., Ltd., MIRAI Technology Institute, Yokohama, Japan.
Summary
Dermal fat infiltration, a common aging process, significantly contributes to wrinkle formation. This fat accumulation impairs skin elasticity, leading to both transient and fixed wrinkles on the forehead.
Area of Science:
- Dermatology
- Aging Research
- Aesthetic Science
Background:
- The precise mechanisms underlying wrinkle formation with aging remain incompletely understood.
- Previous research indicated subcutaneous fat infiltration into the dermis impairs skin elasticity, but its role in wrinkling was unclear.
Purpose of the Study:
- To elucidate the contribution of dermal fat infiltration to wrinkle formation.
- To analyze the relationship between dermal fat infiltration and wrinkle severity in the forehead of middle-aged women.
Main Methods:
- Ultrasonography was used to assess forehead fat infiltration severity in 29 female volunteers.
- Wrinkle severity was evaluated using a 6-grade photographic system, assessing both fixed wrinkles (eyes closed) and transient wrinkles (eyes open).
Main Results:
- Forehead fat infiltration was observed, similar to previous findings in cheek areas.
- A significant positive correlation was found between the severity of fat infiltration and transient wrinkle formation upon eye opening.
- Fat infiltration also significantly correlated with the severity of fixed wrinkles and transient wrinkles.
Conclusions:
- Dermal fat infiltration enhances transient wrinkle formation during facial expressions by reducing skin's resistance to deformation.
- This process promotes the development of fixed wrinkles, establishing fat infiltration as a critical factor in wrinkle formation.
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