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Related Experiment Video

Updated: Aug 5, 2025

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
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Nanofabrication Technologies to Control Cell and Tissue Function in Three-Dimension.

Hidenori Otsuka1

  • 1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.

Gels (Basel, Switzerland)
|March 28, 2023
PubMed
Summary
This summary is machine-generated.

Cellular micropatterning and biomaterials advance drug screening and tissue regeneration. Engineered cell spheroids using hydrogels improve therapeutic outcomes and enable minimally invasive implantation for regenerative medicine.

Keywords:
3D culturePEGylationbiointerfacecell arraymicropatterning

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Microfabrication advances enable cellular micropatterning for drug screening and tissue regeneration.
  • Controlling cell morphology and interactions is crucial for engineered cell scaffolds.
  • Three-dimensional (3D) spheroids offer improved cell survival, function, and engraftment compared to single cells.

Purpose of the Study:

  • This review focuses on surface engineering for cellular micropatterning of 3D spheroids.
  • It examines surface chemistries for creating non-fouling microarrays.
  • The review discusses biomaterials for spheroid engineering and their application in tissue regeneration.

Main Methods:

  • Utilizing microfabrication for cellular micropatterning.
  • Engineering protein-repellent surfaces for cell microarrays.
  • Developing biomaterials like fibers and hydrogels for spheroid formation and interaction control.

Main Results:

  • Cellular micropatterning revolutionizes drug screening by controlling cell morphology and interactions.
  • Biomaterials effectively regulate spheroid formation (size, shape, compaction) and cell-matrix interactions.
  • Injectable hydrogels offer a minimally invasive approach for delivering cell-biomaterial composites in tissue regeneration.

Conclusions:

  • Surface engineering and biomaterial development are critical for advanced cell-based applications.
  • Engineered cell spheroids hold significant promise for enhanced therapeutic effects in regenerative medicine.
  • Injectable hydrogels represent a promising future direction for minimally invasive tissue engineering strategies.