Related Experiment Video

Updated: Aug 5, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K

Magnetic Resonance Left Ventricle Mass-Index/Fibrosis: Long-Term Predictors for Ventricular Arrhythmia in

Habib Rehman Khan1,2, Philip Rodwell1, Ahmed Hasan Taha1,3

  • 1Department of Cardiology, Nottingham University NHS Trust, Hucknall Road, Nottingham NG51PB, UK.

Journal of Cardiovascular Development and Disease
|March 28, 2023
PubMed

Insights

Left ventricular mass index and myocardial fibrosis are linked to ventricular arrhythmias in hypertrophic cardiomyopathy patients. These cardiac magnetic resonance imaging findings can predict long-term arrhythmia risk.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomarkers

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease associated with increased risk of sudden cardiac death.
  • Ventricular arrhythmias (VA) are a major cause of mortality in HCM patients.
  • Identifying reliable predictors of VA is crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the long-term association between left ventricular mass index (LVMI) and myocardial fibrosis (assessed by LV late gadolinium enhancement, LV-LGE) and the occurrence of VA in patients with confirmed HCM.
  • To evaluate LVMI and LV-LGE as potential risk stratification tools for VA in HCM.

Main Methods:

  • Retrospective analysis of 247 HCM patients diagnosed via cardiac magnetic resonance imaging (CMR) between 2008 and 2018.
  • Patients were followed for a mean of 7 years for VA events, with data from cardiac monitoring and ICDs analyzed.
  • Baseline CMR parameters, including LVMI and LV-LGE, were compared between patients with and without VA.

Main Results:

  • Patients who developed VA (Group A) had significantly higher LVMI (91.1 g/m² vs. 78.8 g/m²) and LV-LGE (7.3% vs. 4.7%) compared to those without VA (Group B).
  • Multivariable Cox regression identified both LVMI (HR=1.02) and LV-LGE (HR=1.04) as independent predictors of VA.
  • Cut-off values of LVMI ≥ 85 g/m² and LV-LGE ≥ 6% were associated with increased VA risk.

Conclusions:

  • LVMI and LV-LGE, as measured by CMR, are strongly associated with long-term risk of ventricular arrhythmias in HCM patients.
  • These imaging parameters show potential as valuable tools for risk stratification in HCM.
  • Further research is needed to establish LVMI as a definitive risk stratification tool in HCM.

Keywords:
hypertrophic cardiomyopathy (HCM)implantable cardioverter defibrillation (ICD)late gadolinium enhancement (LGE)left ventricular massleft ventricular wall thicknessrisk stratificationventricular arrhythmia (VA)

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.1K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.4K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
18
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
19
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
20
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
26
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
14
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
27