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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Related Experiment Video

Updated: Aug 5, 2025

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Biodegradable Cements for Bone Regeneration.

Dachuan Liu¹, Chen Cui², Weicheng Chen¹

¹Department of Orthopaedic Surgery, Orthopaedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou 215006, China.

Journal of Functional Biomaterials

|March 28, 2023

Summary

This summary is machine-generated.

Biodegradable bone cements, including calcium phosphates, offer improved bone repair by matching degradation rates with new bone growth. This review explores their mechanisms and clinical applications for better material design.

Keywords:

biodegradable bone cements biomaterials bone regeneration calcium phosphates calcium sulfates

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Last Updated: Aug 5, 2025

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

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Published on: August 8, 2022

Area of Science:

Biomaterials Science
Orthopedic Surgery
Regenerative Medicine

Background:

Bone cements like polymethyl methacrylate and calcium phosphates are clinically successful but have slow degradation rates.
This slow degradation limits their use and poses challenges in matching material resorption with new bone formation.
Understanding degradation mechanisms and composition-property relationships is crucial for developing advanced bone-repair materials.

Purpose of the Study:

To provide a comprehensive overview of current biodegradable bone cements.
To summarize their degradation mechanisms and clinical performance.
To offer insights and references for researchers in bone tissue engineering.

Main Methods:

Literature review of biodegradable bone cements.
Analysis of calcium phosphates (CaP), calcium sulfates, and organic-inorganic composites.
Summary of degradation pathways and clinical outcomes.

Main Results:

Biodegradable bone cements show promise in bone reconstruction.
Calcium phosphates, calcium sulfates, and composites are key materials discussed.
Degradation mechanisms and clinical performance data are synthesized.

Conclusions:

Biodegradable bone cements are essential for advancing bone repair strategies.
Further research into degradation mechanisms can optimize material design.
This review serves as a valuable resource for future development in orthopedic biomaterials.