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Bridging the Bio-Electronic Interface with Biofabrication

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Published on: June 6, 2012

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications.

Simona Petroni¹, Irene Tagliaro², Carlo Antonini²

¹Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milano, Italy.

|March 28, 2023

Summary

Chitosan, a natural polymer from crustacean shells, offers unique properties for advanced biomaterials. This review explores its functionalization and processing into innovative biomedical devices like hydrogels and bioinks.

Keywords:

3D printing chitosan chitosan-based materials drug delivery hydrogels layer-by-layer devices marine-origin polysaccharides organic–inorganic hybrids regenerative medicine tissue engineering

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Area of Science:

Biomaterials Science
Polymer Chemistry
Marine Biotechnology

Background:

Chitosan, derived from chitin, is a naturally abundant polysaccharide with emerging significance.
Recent decades have seen increased interest in chitosan due to its versatile physicochemical and biological properties.
Its applications span various sectors, highlighting its potential in advanced material development.

Purpose of the Study:

To provide a comprehensive overview of chitosan's properties and chemical functionalization.
To review bottom-up strategies for creating diverse chitosan-based biomaterials.
To highlight recent advancements in chitosan biomaterials for biomedical applications.

Main Methods:

Review of chemical functionalization strategies targeting chitosan's amino and hydroxyl groups.
Analysis of bottom-up processing techniques for chitosan biomaterials.
Compilation of recent literature (last 10 years) on chitosan-based hydrogels, hybrids, layer-by-layer assemblies, and (bio)inks.

Main Results:

Chitosan's functional groups allow for versatile chemical modifications.
Various processing strategies enable the creation of advanced chitosan-based materials.
Chitosan biomaterials show significant promise in diverse biomedical applications, including tissue engineering and drug delivery.

Conclusions:

Chitosan is a highly adaptable biopolymer with significant potential for developing next-generation biomedical devices.
Further exploration of chitosan's unique properties will drive innovation in advanced biomaterials.
This review provides insights and inspiration for researchers in the field of chitosan-based biomaterials.