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Correction: Coulter et al. OrgTRx: A Platform Developed in Queensland for the Extraction and Visualisation of Antimicrobial Susceptibility Data for the Surveillance of Resistance in Microorganisms. <i>Antibiotics</i> 2026, <i>15</i>, 63.

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Vancomycin Sequestration in ST Filters: An In Vitro Study.

Frédéric J Baud1,2, Pascal Houzé3, Jean-Herlé Raphalen1

  • 1Département d'Anesthésie et de Réanimation, Adult Intensive Care Unit, Necker Hospital, 75015 Paris, France.

Antibiotics (Basel, Switzerland)
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

This study investigated vancomycin sequestration in ST® filters during continuous renal replacement therapy. Results show no evidence of significant vancomycin sequestration within the ST® filters, ensuring effective drug removal.

Keywords:
adsorptioncontinuous renal replacement therapydialysisfiltrationpharmacokineticssequestrationvancomycin

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Area of Science:

  • Nephrology
  • Pharmacokinetics
  • Biomaterials

Background:

  • Vancomycin sequestration in ST® filters during continuous renal replacement therapy (CRRT) remains unclear.
  • Direct interaction between vancomycin and ST® filters was investigated using in vitro NeckEpur® technology.

Purpose of the Study:

  • To determine if vancomycin is sequestered by ST® filters during CRRT.
  • To assess the direct interaction between vancomycin and ST® filters.

Main Methods:

  • Utilized ST150® filters and Prismaflex dialyzers (Baxter-Gambro).
  • Assessed two CRRT modes: continuous diafiltration (CDF) at 4 L/h and continuous dialysis (CD) at 2.5 L/h post-filtration, in duplicate.
  • Measured vancomycin concentrations in the central compartment (CC) and cumulative effluents over 6 hours.

Main Results:

  • Mean initial vancomycin concentration in CC was 51.4 ± 5.0 mg/L.
  • Mean vancomycin elimination from CC over 6 hours was 91 ± 4%.
  • Mean clearances from CC were 2.8 L/h (CDF) and 1.9 L/h (CD). Mean clearances from effluents were 4.4 L/h (CDF) and 2.2 L/h (CD).
  • Elimination percentages in effluents exceeded 100% (114% CDF, 108% CD), indicating no vancomycin sequestration in ST® filters.

Conclusions:

  • The study found no evidence of significant vancomycin sequestration within ST® filters.
  • Observed clearances align with flow rates, suggesting no increased total clearance due to sequestration.
  • Results indicate ST® filters do not directly sequester vancomycin during CRRT.