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Friend or Foe: Regulation, Downstream Effectors of RRAD in Cancer

Zhangyue Sun1,2, Yongkang Li1,2, Xiaolu Tan1,2

  • 1Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China.

Biomolecules
|March 29, 2023
PubMed

Insights

Ras-related associated with diabetes (RRAD) protein impacts cancer progression and metastasis. Understanding RRAD

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ras-related associated with diabetes (RRAD) is a Ras-related GTPase superfamily member.
  • RRAD is implicated in type 2 diabetes and congestive heart failure.
  • Its role in cancer progression and metastasis is increasingly recognized.

Purpose of the Study:

  • To review the dual role of RRAD as an oncogene or tumor suppressor.
  • To explore RRAD's regulation, downstream effectors, and intracellular functions in cancer.
  • To provide insights for future mechanistic studies and targeted cancer therapies.

Main Methods:

  • Literature review of RRAD's involvement in cancer.
  • Analysis of RRAD's regulatory pathways and downstream interactions.
  • Discussion of RRAD's role in cellular processes like division, motility, apoptosis, and metabolism.

Main Results:

  • RRAD exhibits context-dependent oncogenic or tumor-suppressive functions.
  • RRAD influences tumor cell division, motility, apoptosis, and energy metabolism.
  • RRAD's role in senescence may contribute to its cancer-related functions.

Conclusions:

  • RRAD's complex roles in cancer necessitate further investigation.
  • Targeted therapies focusing on RRAD present a potential strategy for cancer treatment.
  • Understanding RRAD's molecular mechanisms is crucial for developing effective cancer therapies.
Keywords:
RRADcancerdownstream effectorsdual identityregulation

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