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Multiplex Detection of Infectious Diseases on Microfluidic Platforms.

Fumin Chen1,2, Qinqin Hu1,2, Huimin Li1,2

  • 1School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, No. 227 Chongqing South Road, Shanghai 200025, China.

Biosensors
|March 29, 2023
PubMed
Summary

Microfluidic platforms offer automated, miniaturized solutions for multiplex infectious disease detection, overcoming limitations of conventional methods. These advanced technologies are crucial for efficient screening, especially in resource-limited settings during pandemics.

Keywords:
immunosensorsinfectious disease diagnosismicrofluidic platformsmultiplex detectionnucleic acid sensors

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Area of Science:

  • Biomedical Engineering
  • Point-of-Care Diagnostics
  • Infectious Disease Research

Background:

  • Infectious diseases represent a substantial global health burden, necessitating effective screening and containment strategies.
  • Conventional diagnostic methods (e.g., qPCR, DNA sequencing) are often resource-intensive, requiring specialized equipment and personnel, hindering large-scale screening.
  • The need for rapid, accurate, and accessible diagnostic tools is paramount, particularly during outbreaks and in resource-limited environments.

Purpose of the Study:

  • To review recent advancements in microfluidic platforms for the multiplex detection of infectious diseases.
  • To highlight the potential of microfluidics in overcoming the limitations of traditional diagnostic approaches.
  • To discuss challenges, commercialization, and future prospects of microfluidic applications in infectious disease diagnostics.

Main Methods:

  • Exploration of microfluidic platforms, including microfluidic immunosensors and nucleic acid sensors.
  • Detailed discussion of representative microfluidic technologies: lateral flow immunoassay (LFIA) platforms, polymer-based chips, paper-based devices, and droplet-based devices.
  • Analysis of spatial separation capabilities for multiplexed detection of pathogens.

Main Results:

  • Microfluidic platforms enable automated, miniaturized, and integrated detection systems for point-of-care applications.
  • Multiplex detection capabilities reduce misdiagnosis and incomplete diagnoses for diseases with overlapping symptoms.
  • Various microfluidic designs show promise for sensitive and accurate infectious disease screening.

Conclusions:

  • Microfluidic technologies offer a viable alternative to conventional methods for infectious disease detection, particularly for mass screening.
  • These platforms enhance diagnostic efficiency, reduce resource requirements, and improve accessibility in diverse healthcare settings.
  • Further development and commercialization of microfluidic devices are essential to broaden their impact on global public health.