Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

60
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
60
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

52
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
52
Management of Insomnia01:19

Management of Insomnia

292
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
292
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

100
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
100
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

46
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
46
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

35
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How pre-education affects patients choosing appropriate renal replacement treatment: a retrospective study.

BMC nephrology·2026
Same author

Correlates of appendicular skeletal muscle mass in non-dialysis dependent chronic kidney disease men and the control group.

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica·2026
Same author

Hearing Outcomes During Induction Therapy in ANCA-Associated Vasculitis: Applicability of Sudden Sensorineural Hearing Loss Criteria.

Journal of clinical medicine·2026
Same author

Phosphate Excretion Differentiates the Amount of Nephroprotective Effect of Amino Acid Ketoanalogues Treatment with Low Protein Diet in Chronic Kidney Disease-A Retrospective Single-Center Cohort Study.

Journal of clinical medicine·2026
Same author

Coronary Artery-Specific Changes in Patients with Chronic Kidney Disease.

Cells·2026
Same author

Cardiovascular Entropy and Mortality Prediction in Hemodialysis Patients.

Journal of clinical medicine·2026

Related Experiment Video

Updated: Aug 5, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

741

Melatonin Treatment in Kidney Diseases.

Magdalena Markowska1, Stanisław Niemczyk1, Katarzyna Romejko1

  • 1Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, Poland.

Cells
|March 29, 2023
PubMed
Summary

Melatonin, a hormone regulating sleep, shows promise for kidney disease patients. Supplementation offers antioxidant and protective benefits, improving kidney function and well-being with minimal side effects.

Keywords:
acute kidney injurychronic kidney diseasekidney diseasesmelatoninnephrotoxicityrenoprotective effect

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

499
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
07:04

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

10.6K

Related Experiment Videos

Last Updated: Aug 5, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

741
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

499
A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats
07:04

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

10.6K

Area of Science:

  • Neuroendocrinology
  • Nephrology

Background:

  • Melatonin, a pineal gland neurohormone, regulates circadian rhythms and impacts numerous bodily functions.
  • Disruptions in sleep-wake cycles can lead to nervous system imbalance, metabolic, and endocrine issues.
  • Chronic kidney disease (CKD) is linked to cardiovascular, diabetic, and homeostatic derangements, affecting quality of life.

Purpose of the Study:

  • To review the potential benefits of melatonin in kidney diseases.
  • To explore melatonin's indirect connections to kidney function via cardiovascular, diabetic, and homeostatic pathways.
  • To highlight melatonin's role in managing CKD complications.

Main Methods:

  • Literature review of existing studies on melatonin and kidney disease.
  • Analysis of melatonin's antioxidant, free radical scavenging, and cytoprotective properties.
  • Examination of clinical reports on melatonin's impact on renal function and CKD progression.

Main Results:

  • Melatonin exhibits significant antioxidant, free radical scavenging, and cytoprotective effects.
  • Supplementation is beneficial in various kidney injuries due to its anti-inflammatory and anti-apoptotic actions.
  • Melatonin demonstrates a renoprotective effect, inhibiting the progression of renal failure complications.

Conclusions:

  • Melatonin supplementation can be beneficial in nearly all types of kidney injury.
  • Exogenous melatonin administration offers a renoprotective effect and manages CKD complications.
  • Melatonin supplementation is well-tolerated with a low incidence of side effects.