Emergency Department Visits in Children Associated with Exposure to Ambient PM₁ within Several Hours

Emerging evidence has integrated short-term exposure to PM₁ with children's morbidity and mortality. Nevertheless, most available studies have been conducted on a daily scale, ignoring the exposure variations over the span of a day.

The main intention of this study was to examine the association between pediatric emergency department visits (PEDVs) and intra-day exposures to PM₁ and PM_2.5. We also aimed to investigate whether a high PM₁/PM_2.5 ratio elevated the risk of PEDVs independent from PM_2.5 exposure within several hours.

We collected hourly data on aerial PM₁ and PM_2.5 concentrations, all-cause PEDVs, and meteorological factors from two megacities (i.e., Guangzhou and Shenzhen) in southern China during 2015-2016. Time-stratified case-crossover design and conditional logistic regression analysis were used to assess the associations of PEDVs with exposures to PM₁ and PM_2.5 at different lag hours. The contribution of PM₁ to PM_2.5-associated risk was quantified by introducing PM₁/PM_2.5 ratio as an additional exposure indicator in the analysis adjusting for PM_2.5. Subgroup analyses were performed stratified by sex, age, and season.

During this study period, 97,508 and 101,639 children were included from Guangzhou and Shenzhen, respectively. PM₁ and PM_2.5 exposures within several hours were both remarkably related to an increased risk of PEDVs. Risks for PEDVs increased by 3.9% (95% confidence interval [CI]: 2.7-5.0%) in Guangzhou and 3.2% (95% CI: 1.9-4.4%) in Shenzhen for each interquartile range (Guangzhou: 21.4 μg/m³, Shenzhen: 15.9 μg/m³) increase in PM₁ at lag 0-3 h, respectively. A high PM₁/PM_2.5 ratio was substantially correlated with increased PEDVs, with an excess risk of 2.6% (95% CI: 1.2-4.0%) at lag 73-96 h in Guangzhou and 1.2% (95% CI: 0.4-2.0%) at lag 0-3 h in Shenzhen. Stratified analysis showed a clear seasonal pattern in PM-PEDVs relationships, with notably stronger risks in cold months (October to March of the following year) than in warm months (April to September).

Exposures to ambient PM₁ and PM_2.5 within several hours were related to increased PEDVs. A high PM₁/PM_2.5 ratio may contribute an additional risk independent from the short-term impacts of PM_2.5. These findings highlighted the significance of reducing PM₁ in minimizing health risks due to PM_2.5 exposure in children.