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Related Experiment Video

Updated: Aug 5, 2025

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Myopia Is Suppressed by Digested Lactoferrin or Holo-Lactoferrin Administration.

Yifan Liang1,2, Shin-Ichi Ikeda1,2, Junhan Chen1,2

  • 1Laboratory of Photobiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

International Journal of Molecular Sciences
|March 29, 2023
PubMed
Summary

Digested lactoferrin (LF) and holo-LF show greater myopia suppression in mice than native LF. This research highlights potential new interventions for vision impairment caused by myopia.

Keywords:
choroidholo-lactoferrinlactoferricinlactoferrinmyopiasclera

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Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Biochemistry

Background:

  • Myopia is a growing global health concern, leading to significant vision impairment.
  • Lactoferrin (LF) is a protein with potential anti-myopia properties when administered orally.
  • Effective interventions are crucial to manage the increasing prevalence of myopia.

Purpose of the Study:

  • To investigate the efficacy of different forms of lactoferrin (native LF, digested LF, holo-LF) in suppressing myopia progression in a mouse model.
  • To compare the effects of native LF and its derivatives on ocular structures and gene expression related to myopia.

Main Methods:

  • Myopia was induced in mice using minus lenses from 4 weeks of age.
  • Mice received different forms of lactoferrin (native, digested, holo-LF) starting at 3 weeks of age.
  • Axial length, choroidal thickness, and gene expression of myopia-associated factors were analyzed.

Main Results:

  • Mice treated with digested LF or holo-LF exhibited reduced axial elongation and choroidal thinning compared to those receiving native LF.
  • Gene expression analysis revealed lower levels of myopia-associated cytokines and growth factors in groups treated with native LF and its derivatives.
  • Digested LF and holo-LF demonstrated superior efficacy in mitigating myopia progression markers.

Conclusions:

  • Digested lactoferrin and holo-LF are more effective in suppressing myopia progression than native lactoferrin in a mouse model.
  • These findings suggest that specific forms of lactoferrin could be promising therapeutic agents for managing myopia.
  • Further research into lactoferrin derivatives may lead to novel strategies for preventing or treating myopia-induced vision impairment.