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AIEgen-Based Nanomaterials for Bacterial Imaging and Antimicrobial Applications: Recent Advances and Perspectives

Zipeng Shen1, Yinzhen Pan1, Dingyuan Yan1

  • 1Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.

Molecules (Basel, Switzerland)
|March 29, 2023
PubMed

Insights

Aggregation-induced emission luminogens (AIEgens) offer new strategies against multi-drug resistant (MDR) bacterial infections. These nanomaterials combine AIEgens with other materials for enhanced antimicrobial activity via photodynamic and photothermal therapies.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Microbiology

Background:

  • Multi-drug resistant (MDR) bacterial infections pose a significant global health challenge, limiting conventional antibiotic efficacy.
  • Aggregation-induced emission luminogens (AIEgens) are emerging as promising photosensitive antimicrobial materials.
  • AIEgens facilitate microorganism tracing and generate reactive oxygen species (ROS) and/or heat upon light irradiation for targeted antimicrobial therapies.

Purpose of the Study:

  • To review the recent advancements in AIEgen-based nanomaterials for combating microbial infections.
  • To focus on the preparation methods and antimicrobial strategies employed by these novel nanomaterials.
  • To provide an outlook on the future challenges and opportunities in this field.

Main Methods:

  • Review of literature on AIEgen-based nanomaterials for antimicrobial applications.
  • Analysis of material preparation techniques, including combinations with polymers, antibiotics, metal complexes, and peptides.
  • Examination of antimicrobial mechanisms, such as photodynamic therapy (PDT) and photothermal therapy (PTT).

Main Results:

  • AIEgen-based nanomaterials demonstrate potent antimicrobial activity against MDR bacteria.
  • Combining AIEgens with other materials enhances their properties and synergistic antimicrobial effects.
  • These nanomaterials enable fluorescent tracing and light-triggered ROS/heat generation for effective microbial eradication.

Conclusions:

  • AIEgen-based nanomaterials represent a significant breakthrough in addressing MDR infections.
  • Further research into material design and optimization is crucial for clinical translation.
  • Overcoming current challenges will pave the way for novel antimicrobial therapies.
Keywords:
aggregation-induced emissionantimicrobialmulti-drug resistantnanomaterials

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