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Development of pH-Sensitive Magnetoliposomes Containing Shape Anisotropic Nanoparticles for Potential Application in
Ana Rita F Pacheco1,2, Beatriz D Cardoso1,2, Ana Pires3,4
1Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
Nanomaterials (Basel, Switzerland)
|March 29, 2023
Summary
New pH-sensitive solid magnetoliposomes effectively deliver doxorubicin for cancer therapy. These nanocarriers enable controlled drug release and dual hyperthermia, enhancing treatment efficacy while minimizing systemic toxicity.
Area of Science:
- Nanomedicine
- Materials Science
- Oncology
Background:
- Conventional cancer treatments face challenges due to late diagnosis and systemic toxicity.
- Nanomedicine offers a promising avenue for cancer prevention, diagnosis, and treatment.
Purpose of the Study:
- To develop pH-sensitive solid magnetoliposomes (SMLs) for controlled doxorubicin (DOX) release.
- To investigate the potential of SMLs for synergistic cancer therapy, including magnetic targeting and dual hyperthermia.
Main Methods:
- Synthesis and characterization of Mg0.75Ca0.25Fe2O4 magnetic nanoparticles.
- Fabrication of pH-sensitive SMLs encapsulating DOX with high efficiency (>98%).
- Evaluation of DOX release kinetics at different pH values and assessment of SMLs' efficacy on tumor cells.
Main Results:
- Synthesized nanoparticles exhibited superparamagnetic properties and heating capabilities under alternating magnetic field (AMF) and near-infrared (NIR) light.
- DOX-loaded SMLs demonstrated significantly enhanced drug release at acidic pH (pH 5) compared to physiological pH.
- Treatment with DOX-loaded SMLs led to a significant reduction in tumor cell viability.
Conclusions:
- Developed pH-sensitive SMLs are efficient nanocarriers for controlled doxorubicin delivery.
- The SMLs show potential for synergistic cancer therapy through magnetic targeting, stimulus-controlled release, and dual hyperthermia (magnetic and photothermal).
- This approach offers a promising strategy to overcome limitations of conventional cancer treatments.
