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Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review
Igor Longobardi1, Bruno Gualano1,2, Antonio Carlos Seguro3
1Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, School of Medicine, University of Sao Paulo, Sao Paulo 01246-903, SP, Brazil.
Nutrients
|March 29, 2023
Summary
Creatine supplements are safe for most people, despite concerns about kidney health. Clinical studies show no evidence of kidney damage from creatine use in healthy individuals.
Area of Science:
- Sports Nutrition
- Dietary Supplements
- Kidney Health
Background:
- Creatine is a popular supplement for athletes and clinical populations.
- Concerns exist regarding creatine's potential adverse effects on kidney function.
- Existing research presents conflicting evidence on creatine and kidney health.
Purpose of the Study:
- To review the scientific literature on the effects of creatine supplementation on kidney function.
- To evaluate the safety of creatine for kidney health in various populations.
- To clarify the relationship between creatine supplementation and serum creatinine levels.
Main Methods:
- Narrative review of existing clinical trials and studies.
- Analysis of case reports and animal studies.
- Assessment of kidney function using reliable methodologies.
Main Results:
- Controlled clinical trials do not support claims of creatine-induced kidney impairment.
- Increased serum creatinine (Crn) levels in some users do not indicate kidney dysfunction.
- Evidence suggests creatine supplements are safe for general human consumption.
Conclusions:
- Creatine supplementation is considered safe for kidney function in healthy individuals.
- Further research is needed to assess safety in individuals with pre-existing kidney disease.
- Distinguishing between creatine supplementation effects and actual kidney dysfunction is crucial.
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