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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

94
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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3D Printing of In Vitro Hydrogel Microcarriers by Alternating Viscous-Inertial Force Jetting
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Emerging Trends in Biodegradable Microcarriers for Therapeutic Applications.

Harish K Handral1, Tom Adam Wyrobnik1,2, Alan Tin-Lun Lam1

  • 1Stem Cell Bioprocessing, Bioprocessing Technology Institute, A*STAR, Singapore 138668, Singapore.

Polymers
|March 29, 2023
PubMed
Summary
This summary is machine-generated.

Biodegradable microcarriers offer a promising solution for cell therapy production and regenerative medicine. These advanced platforms enable efficient cell expansion and delivery, improving therapeutic outcomes and reducing costs.

Keywords:
biodegradablecell manufacturingcell therapymesenchymal stem cellsmicrocarriersregenerative medicinestem cells

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Microcarriers (MCs) are versatile tools in regenerative medicine and drug delivery, used for cell expansion, tissue engineering scaffolds, and therapeutic compound delivery.
  • Current microcarrier technologies face challenges in large-scale cell therapy production, including reduced cell yield and quality due to harvesting and dissociation steps.

Purpose of the Study:

  • To review biodegradable microcarrier platforms for clinical-grade cell generation.
  • To highlight their potential in cell delivery, tissue repair, and biopharmaceutical applications.

Main Methods:

  • Compilation of key information on biodegradable microcarrier platforms.
  • Analysis of their properties for cell expansion, delivery, and tissue engineering.

Main Results:

  • Biodegradable MCs facilitate the generation of clinical-grade cells with high yield and quality.
  • They serve as injectable scaffolds for defect filling and deliver biochemical signals for tissue regeneration.
  • Integration with bioinks enhances 3D bioprinted structures and bioactive profiles.

Conclusions:

  • Biodegradable microcarriers are crucial for overcoming challenges in cell therapy production and enabling advanced applications.
  • Their tunable biodegradation and versatility benefit in vitro disease modeling and the biopharmaceutical industry.