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2B-Alert App 2.0: personalized caffeine recommendations for optimal alertness.

Francisco G Vital-Lopez1,2, Tracy J Doty3, Ian Anlap4

  • 1Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD, USA.

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Personalized caffeine recommendations from the 2B-Alert app help maintain alertness during sleep loss. The app learns individual responses to sleep deprivation, optimizing caffeine intake for sustained cognitive function.

Keywords:
alertnesscaffeinemathematical modelpersonalized predictionssleep losssmartphone app

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Applied Technology

Background:

  • Caffeine effectively mitigates sleep loss effects on alertness.
  • Lack of personalized tools hinders optimal caffeine consumption for alertness.
  • Smartphone applications offer potential for real-time physiological monitoring and guidance.

Purpose of the Study:

  • To extend the 2B-Alert app's capabilities for personalized caffeine recommendations.
  • To optimize alertness by tailoring caffeine intake to individual sleep-loss responses.
  • To validate the app's effectiveness in a controlled sleep deprivation study.

Main Methods:

  • Prospective validation in a 62-hour total sleep deprivation study with 21 participants.
  • Utilized the psychomotor vigilance test (PVT) for alertness measurement via the 2B-Alert app.
  • App learned individual sleep-loss responses within 36 hours to provide real-time caffeine recommendations.

Main Results:

  • Participants received personalized caffeine recommendations ranging from 0 to 800 mg.
  • Despite varying caffeine amounts, participants maintained target alertness levels approximately 80% of the time.
  • The app successfully guided caffeine consumption to sustain alertness.

Conclusions:

  • The 2B-Alert app automatically learns individual phenotypes for sleep-loss response.
  • Personalized, real-time caffeine recommendations enable desired alertness levels.
  • The app provides a novel tool for managing alertness irrespective of sleep-loss susceptibility.