Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

True Stress and True Strain01:28

True Stress and True Strain

366
Engineering stress is calculated as the load divided by the original, undeformed cross-sectional area. It approximates a material under load. This approximation is especially relevant post-yield in ductile materials. Though engineering stress-strain diagrams are often used for their convenience and accessibility, they can sometimes fall short in accuracy, particularly when dealing with large strain values.
In contrast, true stress offers a more precise portrayal. It is computed by dividing the...
366

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac patterns for differentiation of neurogenic stunned myocardium in aneurysmal subarachnoid hemorrhage versus acute ischemic stroke.

Echocardiography (Mount Kisco, N.Y.)·2023
Same author

Prognostic implications of mitral valve geometry in patients with secondary mitral regurgitation: the COAPT trial.

European heart journal. Cardiovascular Imaging·2022
Same author

Pericardiocentesis induced right ventricular changes in patients with and without pulmonary hypertension.

Echocardiography (Mount Kisco, N.Y.)·2021
Same author

Tricuspid valve injury after heart transplantation: how to monitor for rejection?

European heart journal. Cardiovascular Imaging·2021
Same author

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography.

Journal of visualized experiments : JoVE·2020
Same author

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography.

Journal of visualized experiments : JoVE·2020

Related Experiment Video

Updated: Aug 5, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

19.7K

Predictive value of global longitudinal strain by left ventricular ejection fraction.

Diego Medvedofsky1, Genevieve Arany-Lao-Kan2,3, Scott McNitt2

  • 1MedStar Washington Hospital Center, Washington, DC, USA.

ESC Heart Failure
|March 29, 2023
PubMed
Summary

Left ventricular global longitudinal strain (GLS) predicts adverse outcomes in heart failure patients with reduced ejection fraction (LVEF ≤ 30%). However, GLS did not predict outcomes in patients with preserved ejection fraction (LVEF > 30%).

Keywords:
Clinical outcomesEjection fractionGlobal longitudinal strainLeft ventricular functionVentricular arrhythmias

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.0K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.4K

Related Experiment Videos

Last Updated: Aug 5, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

19.7K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.0K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.4K

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Management

Background:

  • The prognostic value of left ventricular (LV) global longitudinal strain (GLS) across different left ventricular ejection fraction (LVEF) categories remains unclear.
  • Assessing LV GLS in heart failure (HF) patients stratified by LVEF is crucial for refining risk prediction.

Purpose of the Study:

  • To evaluate the predictive capability of LV GLS for clinical outcomes in heart failure patients with varying LVEF.
  • To determine if LV GLS provides incremental prognostic information beyond traditional parameters in different LVEF subgroups.

Main Methods:

  • Analysis of 1077 patients from the MADIT-CRT trial with available 2D speckle tracking data.
  • Stratification of patients into LVEF ≤ 30% (n=640) and LVEF > 30% (n=437) groups.
  • Assessment of primary (ventricular tachycardia/fibrillation or death) and secondary (heart failure or death) endpoints based on LV GLS tertiles.

Main Results:

  • In patients with LVEF ≤ 30%, higher LV GLS tertiles correlated with increased rates of VT/VF/death and HF/death.
  • LV GLS independently predicted VT/VF or death (T1 vs. T2/3 HR=1.67) and HF/death (T1 vs T2/3 HR=2.00) in the LVEF ≤ 30% group.
  • These predictive associations were not significant in the LVEF > 30% subgroup.

Conclusions:

  • LV GLS is a valuable independent predictor of adverse outcomes (VT/VF, HF/death) in heart failure patients with LVEF ≤ 30%.
  • LV GLS does not appear to offer significant prognostic value in heart failure patients with LVEF > 30% within the MADIT-CRT cohort.
  • These findings highlight the importance of LVEF in the interpretation of LV GLS for risk stratification in heart failure.