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Updated: Aug 5, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
[Dupilumab: beyond atopic dermatitis, off-label use in dermatology]
Giuseppe Russo1, Emmanuel Laffitte1
1Service de dermatologie et vénéréologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
Dupilumab is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor inhibiting the signaling of interleukin-4 and interleukin-13, two major cytokines in type 2 inflammatory diseases such as atopic dermatitis, asthma and nasosinusal polyposis. Since its approval for atopic dermatitis in 2017, the molecule has occasionally been used off-label in several dermatological conditions where standard treatments are often disappointing.Furthermore, what emerges from the data currently in the literature is a favourable safety profile with few, reversible side effects.
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