Cardiac MRI-Based Assessment of Myocardial Injury in Asymptomatic People Living With Human Immunodeficiency Virus:
Xin Peng1, Haibo Ding2,3,4,5, Huaibi Huo1
1Department of Radiology, The First Hospital of China Medical University, Shenyang, China.
Insights
Asymptomatic individuals living with HIV show subclinical myocardial inflammation and dysfunction. Lower CD4 counts are linked to increased risk of myocardial injury in these patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Imaging
Background:
- Cardiac manifestations of HIV are known, but subclinical findings in asymptomatic individuals require further exploration.
- Understanding myocardial health in people living with HIV (PLWH) is crucial for comprehensive care.
Purpose of the Study:
- To assess subclinical myocardial injury in asymptomatic PLWH using cardiac MRI.
- To investigate the association between myocardial injury and HIV-related clinical characteristics.
Main Methods:
- A cross-sectional study involving 80 asymptomatic PLWH and 50 healthy controls.
- Cardiac MRI with cine, T1, T2, and T2* mapping sequences at 3-T.
- Feature tracking for function analysis and region of interest analysis for T1, T2, T2* values; nadir CD4 count was assessed.
Main Results:
- Asymptomatic PLWH exhibited higher native myocardial T1 and T2 values, and reduced global longitudinal, radial, and circumferential strain compared to controls.
- No significant difference in T2* values was observed.
- A negative correlation was found between native T1 increment and nadir CD4 count; lower nadir CD4 counts (<500 cells/mm³) were associated with elevated T1 values.
Conclusions:
- Subclinical myocardial inflammation and dysfunction are present in asymptomatic PLWH.
- Lower nadir CD4 count is a potential risk factor for subclinical myocardial injury in this population.
Background:
There are known cardiac manifestations of HIV, but the findings in asymptomatic subjects are still not fully explored.
Purpose:
To evaluate for the presence of subclinical myocardial injury in asymptomatic people living with human immunodeficiency virus (PLWH) by cardiac MRI and to explore the possible association between subclinical myocardial injury and HIV-related clinical characteristics.
Study Type:
Cross-sectional.
Population:
A total of 80 asymptomatic PLWH (age: 53 years [47-56 years]; 90% male) and 50 age- and sex-matched healthy participants.
Field Strength/Sequence:
A 3-T, cine sequence, T1, T2, and T2* mapping.
Assessment:
Function analysis was derived from short axis, two-, three-, and four-chamber cine images by feature tracking. Regions of interest were manually selected in the midventricular septum T1, T2, and T2* mapping sequences. PLWH were evaluated for T1 increment (△T1 mapping = native T1 - cutoff values) and HIV-related clinical characteristics, particularly the nadir CD4 count. And PLWH were stratified into two groups according to the cutoff value of native T1: elevated native T1 and normal.
Statistical Tests:
T test, Wilcoxon rank-sum test, Chi-square test, Spearman rank correlation, and logistic regression. P <0.05 indicated statistical significance.
Results:
Asymptomatic PLWH revealed significantly higher native myocardial T1 values (1241 ± 29 msec vs. 1189 ± 21 msec), T2 values (40.7 ± 1.5 msec vs. 37.9 ± 1.4 msec), and lower LVGRS (30.2% ± 6.2% vs. 35.8% ± 6.4%), LVGCS (-18.0% ± 2.5% vs. -19.5% ± 2.0%), and LVGLS (-16.0% ± 3.8% vs. -17.9% ± 2.6%) but showed no difference in T2* values (17.3 msec [16.3-19.1 msec] vs. 18.3 msec [16.5-19.3 msec], P = 0.201). A negative correlation between the native T1 increment in PLWH with subclinical myocardial injury and the nadir CD4 count (u = -0.316). Nadir CD4 count <500 cells/mm3 was associated with higher odds of elevated native T1 myocardial values (odds ratio, 6.12 [95% CI, 1.07-34.91]) in PLWH.
Data Conclusion:
Subclinical myocardial inflammation and dysfunction were present in asymptomatic PLWH, and a lower nadir CD4 count may be a risk factor for subclinical myocardial injury.
Evidence Level:
1.
Technical Efficacy:
Stage 2.
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