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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Updated: Aug 5, 2025

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Food-Induced Anaphylaxis: Data From the European Anaphylaxis Registry.

Sabine Dölle-Bierke1, Veronika Höfer1, Wojciech Francuzik1

  • 1Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.

The Journal of Allergy and Clinical Immunology. in Practice
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PubMed
Summary

Food-induced anaphylaxis (FIA) varies by age, with different common triggers for children and adults. Factors like exercise and alcohol can increase the severity of specific food allergies.

Keywords:
CashewFood anaphylaxisHazelnutPeanutPhenotypeRisk factorsShellfishWheat

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Area of Science:

  • Allergy and Immunology
  • Clinical Medicine
  • Epidemiology

Background:

  • Food allergy is a growing public health concern, with food-induced anaphylaxis (FIA) incidence increasing.
  • Identifying specific food triggers and associated risk factors is crucial for managing FIA.

Purpose of the Study:

  • To characterize elicitor-specific phenotypes in FIA.
  • To identify factors that increase the risk or severity of FIA.

Main Methods:

  • Analysis of 3,427 confirmed FIA cases from the European Anaphylaxis Registry.
  • Age- and sex-matched analysis using Cramer's V for trigger associations and odds ratios (ORs) for severe FIA.

Main Results:

  • Age-dependent elicitor ranking identified: peanut, cow's milk, cashew, hen's egg (children); wheat flour, shellfish, hazelnut, soy (adults).
  • Wheat-induced anaphylaxis linked to cardiovascular symptoms; cashew-induced anaphylaxis to gastrointestinal symptoms.
  • Exercise strongly associated with wheat FIA; alcohol intake with wheat FIA severity; exercise with peanut FIA severity.

Conclusions:

  • FIA triggers and presentation are age-dependent, with a broader range of elicitors in adults.
  • Specific elicitors may influence FIA severity, necessitating further research to distinguish risk and augmentation factors.