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Updated: Aug 5, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
CT Perfusion vs Noncontrast CT for Late Window Stroke Thrombectomy: A Systematic Review and Meta-analysis.
Hassan Kobeissi1, Sherief Ghozy2, Gautam Adusumilli2
1From the Department of Radiology (H.K., S.G., C.B., M.A., R.K., W.B., D.F.K.), Mayo Clinic, Rochester, MN; College of Medicine (H.K.), Central Michigan University, Mount Pleasant; Department of Radiology (G.A.), Massachusetts General Hospital, Boston; Department of Neurology (H.T.), Medical College of Wisconsin, Milwaukee; Department of Neurologic Surgery (R.K.), Mayo Clinic, Rochester, MN; Department of Radiology and Neurosurgery (J.J.H.), Stanford University, CA; and Department of Neurology (A.A.R.), Mayo Clinic, Rochester, MN. kobei1h@cmich.edu.
For acute ischemic stroke patients undergoing late-window endovascular thrombectomy, CT perfusion imaging did not improve functional independence rates compared to noncontrast CT alone. However, CT perfusion selection was associated with lower mortality rates.
Area of Science:
- Neurology
- Radiology
- Interventional Cardiology
Background:
- Acute ischemic stroke (AIS) patients treated with endovascular thrombectomy (EVT) in the late window (6-24 hours) can be evaluated using CT perfusion (CTP) or noncontrast CT (NCCT) only.
- The comparative effectiveness of these imaging modalities for patient selection remains unclear.
Conclusions:
- CTP selection for late-window EVT in AIS does not improve functional independence rates compared to NCCT alone.
- However, CTP-guided selection is associated with reduced mortality, suggesting potential benefits in patient management.
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