Related Experiment Video

Updated: Aug 4, 2025

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
07:32

Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis

Published on: March 28, 2025

520

Mycobacterium trehalose polyphleates are required for infection by therapeutically useful mycobacteriophages BPs and

Katherine S Wetzel, Morgane Illouz, Lawrence Abad

    Biorxiv : the Preprint Server for Biology
    |March 30, 2023
    PubMed

    Insights

    Surface-exposed trehalose polyphleates (TPPs) are crucial for mycobacteriophage infection. Loss of TPPs on bacterial cell surfaces confers phage resistance, a key mechanism in mycobacterial infections.

    Area of Science:

    • Microbiology
    • Virology
    • Molecular Biology

    Background:

    • Mycobacteriophages are valuable models for studying bacterial hosts.
    • Phage therapy shows potential for treating nontuberculous mycobacterium infections.
    • Mechanisms of phage-host interactions and resistance in mycobacteria are poorly understood.

    Conclusions:

    • TPPs are critical determinants of mycobacteriophage recognition and infection.
    • TPP loss is a major mechanism of phage resistance in *Mycobacterium* species.
    • Developing TPP-independent phage mutants offers a promising strategy to circumvent phage resistance in clinical settings.

    More Related Videos

    Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice08:46

    Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice

    Published on: January 26, 2024

    1.7K
    Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes08:34

    Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

    Published on: September 27, 2018

    8.7K

    Related Concept Videos

    Bacterial Phylum Tenericutes01:24

    Bacterial Phylum Tenericutes

    The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
    47
    DNA Bacteriophages01:26

    DNA Bacteriophages

    Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
    72
    Lytic Cycle of Bacteriophages01:30

    Lytic Cycle of Bacteriophages

    Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
    71.3K
    Bacterial Phylum Actinobacteria01:30

    Bacterial Phylum Actinobacteria

    Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
    46
    Defense Against Bacterial Pathogens01:31

    Defense Against Bacterial Pathogens

    The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
    Phagocytes
    Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
    1.5K
    Bacterial Phylum Planctomycetes01:26

    Bacterial Phylum Planctomycetes

    Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...
    38