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Multifocal small bowel lymphoma and latent celiac sprue
Gastroenterology
|June 1, 1986
Summary
Latent celiac sprue may be present in patients with lymphoma. A high-gluten diet induced celiac sprue-like abnormalities in a lymphoma patient, which resolved on a gluten-free diet.
Area of Science:
- Gastroenterology
- Oncology
- Immunology
Background:
- Malignant small intestinal lymphoma can precede or coincide with celiac sprue diagnosis.
- Celiac sprue is increasingly recognized in subclinical or occult forms.
Observation:
- A 73-year-old woman with a history of jejunoileal lymphoma underwent a 4-week high-gluten diet (40g daily).
- Proximal small bowel biopsy specimens were initially normal prior to the gluten challenge.
Findings:
- The high-gluten diet induced small intestinal biopsy abnormalities characteristic of celiac sprue.
- These abnormalities resolved within 6 weeks after resuming a gluten-free diet.
Implications:
- This case suggests latent celiac sprue may exist in lymphoma patients.
- The association between celiac sprue and lymphoma may be underestimated.
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