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Updated: Aug 4, 2025

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

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Published on: May 26, 2022

Hydralazine-Induced Vasculitis.

Pulkit Gandhi¹, Bani Khurana², Ripudaman S Munjal³

¹Nephrology, Rochester Regional Health, Rochester, USA.

|March 30, 2023

Summary

This summary is machine-generated.

Hydralazine can rarely cause vasculitis, a serious side effect. This case report details hydralazine-induced vasculitis presenting as worsening kidney function in a 67-year-old female.

Keywords:

anca-associated vasculitis drug-induced acute kidney injury hydralazine-induced vasculitis immunosuppression rituximab therapy

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Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Area of Science:

Nephrology
Rheumatology
Internal Medicine

Background:

Hydralazine is a widely used antihypertensive medication.
While generally safe, it carries a risk of rare adverse effects, including drug-induced vasculitis.
Vasculitis can manifest with diverse clinical presentations, impacting multiple organ systems.

Observation:

A 67-year-old female with multiple comorbidities presented with worsening kidney function.
Urinalysis revealed hematuria and proteinuria.
Elevated myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) titers were detected.

Findings:

Renal biopsy demonstrated focal crescentic glomerulonephritis, red blood cell casts, and acute tubular necrosis.
Mild interstitial fibrosis (<20%) was noted.
The clinical and pathological findings led to a diagnosis of hydralazine-induced vasculitis.

Implications:

This case highlights the importance of considering drug-induced vasculitis in patients presenting with unexplained kidney injury.
Early recognition and withdrawal of the offending agent (hydralazine) are crucial for managing this condition.
Increased awareness among clinicians can improve patient outcomes by facilitating timely diagnosis and treatment.