Related Experiment Video
Updated: Aug 4, 2025

Application of Laparoscopic Partial Splenectomy with Total Blood Flow Occlusion in Benign Splenic Lesions
Published on: December 20, 2024
COVID-19 and splenectomy: Education matters
1Internal Medicine Department, Centre National de Référence des Cytopénies Auto-Immunes de l'adulte, Hôpital Henri Mondor, Fédération Hospitalo-Universitaire TRUE InnovaTive theRapy for immUne disordErs, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris Est Créteil, Créteil, France.
Splenectomized patients experienced higher COVID-19 hospitalization and mortality rates, even with similar infection rates. This highlights increased vulnerability in individuals without a spleen.
Area of Science:
- Infectious Diseases
- Hematology
- Public Health
Background:
- The impact of splenectomy on COVID-19 outcomes remains unclear.
- Splenectomized individuals may have altered immune responses, potentially affecting disease severity.
Purpose of the Study:
- To investigate COVID-19-related morbidity and mortality in splenectomized patients.
- To compare infection rates between splenectomized and non-splenectomized populations.
Main Methods:
- Retrospective observational study design.
- Analysis of data from Apulian splenectomized patients.
Main Results:
- Splenectomized patients showed increased rates of COVID-19 hospitalization.
- Higher mortality rates were observed in splenectomized individuals.
- Infection rates were similar between splenectomized and general populations.
Conclusions:
- Splenectomy is associated with increased burden of COVID-19 disease.
- Patients without a spleen face higher risks of severe outcomes from COVID-19.
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04:00Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
08:04A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
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