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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Programming Nucleation and Growth in Colloidal Crystals Using DNA.

Kaitlin M Landy1,2, Kyle J Gibson1,2, Rachel R Chan1,2

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.

ACS Nano
|March 30, 2023
PubMed
Summary
This summary is machine-generated.

DNA sequence design separates nucleation and growth in colloidal crystallization, enhancing crystal uniformity and size control. This method improves material properties for device applications.

Keywords:
biomaterialsnanomaterialsnanoparticlesnanotechnologyself-assembly

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • Colloidal crystal engineering using DNA enables control over lattice symmetry and parameters.
  • Current slow-cooling methods limit control over crystal size and uniformity due to inseparable nucleation and growth.

Purpose of the Study:

  • To explore DNA sequence design for separating nucleation and growth in colloidal crystallization.
  • To improve crystal uniformity and size control in DNA-templated colloidal crystals.

Main Methods:

  • Designed two batches of complementary DNA-coated particles: one with perfect complementarity (seeds) and one with a strategic mismatch (growth).
  • Utilized heterogeneous growth of weaker-binding particles onto stronger-binding nucleates to eliminate secondary nucleation.
  • Synthesized core-shell colloidal crystals using gold and silver particle cores in a one-pot method.

Main Results:

  • Achieved improved crystal uniformity, reducing polydispersity from PDI = 0.201 to 0.091.
  • Demonstrated separation of nucleation and growth by tuning DNA interaction strength.
  • Successfully synthesized core-shell colloidal crystals via a one-pot approach.

Conclusions:

  • DNA sequence design offers a powerful strategy to control colloidal crystal size, uniformity, and structure.
  • This approach is crucial for developing DNA-templated colloidal crystals as advanced device components.
  • Separating nucleation and growth is key to overcoming limitations in current colloidal crystallization techniques.