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Prevention of invasive ventilation (PRiVENT)-a prospective, mixed-methods interventional, multicentre study with a

Julia D Michels1,2, Jan Meis3, Noemi Sturm4

  • 1Department of Pneumology and Critical Care, Heidelberg, Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Thoraxklinik Heidelberg gGmbH, Heidelberg, Germany. Julia.Michels@med.uni-heidelberg.de.

BMC Health Services Research
|March 30, 2023
PubMed

Insights

This study evaluates strategies to prevent long-term invasive mechanical ventilation (IMV) in intensive care patients. The goal is to improve patient outcomes and reduce healthcare costs associated with prolonged ventilation.

Area of Science:

  • Critical Care Medicine
  • Pulmonology
  • Health Services Research

Background:

  • Invasive mechanical ventilation (IMV) is crucial for respiratory failure but leads to challenges in weaning, increased costs, and prolonged resource use.
  • Aging populations and comorbidities contribute to a rising number of patients requiring long-term IMV.
  • Effective strategies are needed to prevent prolonged mechanical ventilation and improve patient quality of life.

Purpose of the Study:

  • To evaluate strategies aimed at preventing long-term invasive mechanical ventilation (IMV).
  • To enhance weaning expertise and collaboration between intensive care units (ICUs) and specialized weaning centers.
  • To reduce the incidence of prolonged IMV and its associated negative consequences.

Main Methods:

  • A prospective, mixed-methods, interventional, multicenter study (PRiVENT) conducted over 24 months in Germany.
  • Utilizing insurance claims data from AOK-BW for patient selection and comparison.
  • Employing mixed logistic regression models to evaluate the primary outcome of successful weaning from IMV.

Main Results:

  • The study is designed to evaluate the primary outcome of successful weaning from IMV.
  • Secondary outcomes will be assessed using mixed regression models.
  • Results will inform the effectiveness of implemented weaning strategies.

Conclusions:

  • The PRiVENT project aims to identify and assess effective strategies for preventing long-term IMV.
  • Improving weaning processes and inter-unit cooperation is a key objective.
  • Successful implementation of these strategies could significantly improve patient care and resource allocation in ICUs.
Abstract

Keywords:
Invasive mechanical ventilationMedical education and trainingRespiratory failureWeaningWeaning failure

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