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Updated: Aug 4, 2025
Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
Published on: June 26, 2017
Ultra-widefield and high-speed spiral laser scanning OR-PAM: System development and characterization
Mohsin Zafar1,2, Rayyan Manwar1, Laura S McGuire3
1The Richard and Loan Hill, Department of Biomedical Engineering, University of Illinois at Chicago, Chicago, Illinois, USA.
Abstract:
Photoacoustic microscopy (PAM) is a high-resolution imaging modality that has been mainly implemented with small field of view applications. Here, we developed a fast PAM system that utilizes a unique spiral laser scanning mechanism and a wide acoustic detection unit. The developed system can image an area of 12.5 cm2 in 6.4 s. The system has been characterized using highly detailed phantoms. Finally, the imaging capabilities of the system were further demonstrated by imaging a sheep brain ex vivo and a rat brain in vivo.
