Introversion and Neuroticism in Akinetic-Rigid Parkinson's Disease: Association With Frontal-Executive Dysfunction
Natascia De Lucia1, Anna De Rosa1, Sandra Perillo1
1Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples (De Lucia, De Rosa, Perillo, De Michele, Maldonato); Postgraduate School of Integrated Gestalt Psychotherapy, Torre Annunziata, Italy (Sperandeo).
The Journal of Neuropsychiatry and Clinical Neurosciences
|March 31, 2023
Summary
Individuals with akinetic-rigid Parkinson's disease (PD) show distinct personality traits and cognitive deficits. These findings link specific personality profiles to motor subtypes, aiding in understanding PD
Area of Science:
- Neuroscience
- Psychology
- Movement Disorders
Background:
- Personality changes are common in Parkinson's disease (PD).
- Limited research exists on the links between personality, cognition, and motor symptoms in PD.
- Specific motor subtypes of PD may have unique psychological and cognitive profiles.
Purpose of the Study:
- To investigate associations between personality traits and specific motor subtypes of Parkinson's disease (PD).
- To examine the relationship between frontal-executive functions and personality traits in PD patients with distinct motor phenotypes.
Main Methods:
- The study included 41 individuals with PD and 40 healthy controls.
- Participants underwent comprehensive assessments of cognitive function, psychological status, and personality traits.
- PD patients were categorized into tremor-dominant and akinetic-rigid subtypes.
Main Results:
- Akinetic-rigid PD patients exhibited poorer frontal-executive function compared to tremor-dominant PD patients.
- Akinetic-rigid PD patients showed higher levels of psychopathological symptoms, neuroticism, and introversion.
- In akinetic-rigid PD, personality traits (neuroticism, introversion) and psychopathology correlated with executive dysfunction; no such links were found in tremor-dominant PD.
Conclusions:
- Specific personality and executive function profiles characterize the akinetic-rigid subtype of Parkinson's disease.
- These findings contribute to a more nuanced understanding of PD's clinical heterogeneity.
- Further research into psychological, personality, and cognitive mechanisms in PD may inform targeted therapeutic strategies.
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