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Updated: Aug 4, 2025
Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Crosstalk between triple negative breast cancer and microenvironment
Karly Smrekar1, Artem Belyakov1, Kideok Jin1
1Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Science, Albany, NY 12208, USA.
Abstract:
Although many advances have been made in the treatment of breast cancer, for the triple negative breast cancer (TNBC) these therapies have not significantly increased overall survival. Tumor microenvironment (TME) plays an essential role to develop and control TNBC progression. Many preclinical and clinical studies are ongoing to treat patients with TNBC disease, but the effective therapies are currently not available. Here, we have reviewed recent progress in understanding of TNBC and advance in defining mechanisms of TNBC therapies and potential therapeutic strategies to overcome TNBC.
Insights
Triple-negative breast cancer (TNBC) remains challenging to treat, with limited survival improvements. This review explores TNBC mechanisms and therapeutic strategies, focusing on the tumor microenvironment (TME) to identify effective treatments.
Area of Science:
- Oncology
- Cancer Biology
- Immunology
Background:
- Triple-negative breast cancer (TNBC) lacks targeted therapies, significantly impacting patient survival rates.
- The tumor microenvironment (TME) is a critical factor in TNBC development and progression.
- Current treatment advancements have not substantially improved overall survival for TNBC patients.
Purpose of the Study:
- To review recent progress in understanding TNBC biology.
- To define the mechanisms underlying current and emerging TNBC therapies.
- To identify potential therapeutic strategies to overcome TNBC challenges.
Main Methods:
- Literature review of preclinical and clinical studies on TNBC.
- Analysis of research on the role of the tumor microenvironment in TNBC.
- Synthesis of information on therapeutic strategies and their mechanisms.
Main Results:
- TNBC remains a significant clinical challenge with limited therapeutic options.
- The TME critically influences TNBC progression and treatment response.
- Understanding TNBC mechanisms is crucial for developing effective therapies.
Conclusions:
- Effective therapies for TNBC are urgently needed.
- Targeting the TME presents a promising strategy for TNBC treatment.
- Further research into TNBC mechanisms can guide the development of novel therapeutic approaches.
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