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Correlation of elevated serum uric acid with coronary artery disease in Xinjiang, China: A retrospective case-control

Hua-Yin Li1,2, Hong-Yu Ji1,2, Gulinigaer Maimaitituersun1,2

  • 1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.

Medicine
|March 31, 2023
PubMed

Insights

Elevated serum uric acid (SUA) is linked to coronary artery disease (CAD) but is not an independent risk factor. SUA correlates with other cardiovascular risk factors, not CAD severity, in Xinjiang, China.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Epidemiology

Background:

  • Elevated serum uric acid (SUA) is associated with coronary artery disease (CAD).
  • The independence of this association from traditional cardiovascular risk factors is debated.
  • Understanding SUA's role in CAD is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate serum uric acid (SUA) concentrations in relation to the presence and severity of coronary artery disease (CAD).
  • To assess the association between SUA levels and cardiometabolic risk factors in a multi-ethnic population in Xinjiang, China.
  • To determine if SUA is an independent risk factor for CAD.

Main Methods:

  • Cross-sectional study involving 412 patients undergoing percutaneous coronary intervention (PCI) and 845 controls with normal coronary angiograms.
  • CAD severity was quantified using the Gensini score.
  • Logistic regression analysis was employed to identify risk factors for PCI.

Main Results:

  • Serum uric acid (SUA) levels were significantly higher in patients with coronary artery disease (CAD) compared to controls (P < .01).
  • SUA showed a significant positive correlation with total cholesterol, triglycerides, LDL cholesterol, and creatinine in both sexes.
  • No significant correlation was found between SUA levels and CAD severity (Gensini score) in the PCI group.

Conclusions:

  • Serum uric acid (SUA) is not an independent risk factor for coronary artery disease (CAD).
  • In the studied population in Xinjiang, China, SUA is associated with multiple cardiovascular risk factors but not with the severity of CAD.
  • Further research may clarify the clinical implications of SUA in cardiovascular disease management.

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