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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
Published on: August 15, 2019
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A double-edged sword: DLG5 in diseases
Xin-Qiu Song1, Qian Li2, Jing Zhang1
1Medical College of Yan'an University, Yan'an University, Yan'an 716000, Shaanxi Province, China.
Summary
Discs large homolog 5 (DLG5) is a scaffold protein involved in cell adhesion and polarity. This review examines DLG5
Area of Science:
- Cell Biology
- Molecular Biology
- Oncology
Background:
- Discs large homolog 5 (DLG5), a MAGUK family member, acts as a scaffold protein crucial for signal transduction and epithelial polarity.
- DLG5 influences cell adhesion and tight junction complexes in various tissues.
- Dysregulation of DLG5 is implicated in diseases, including Crohn's disease and cancers.
Purpose of the Study:
- To review the existing literature on the role of DLG5 and its variants in disease.
- To summarize current data on DLG5's involvement in disease pathogenesis.
- To highlight the therapeutic potential of DLG5 in disease treatment.
Main Methods:
- Literature review of studies on DLG5 and disease.
- Analysis of data from cell experiments, clinical samples, and animal models.
- Evaluation of DLG5's interactions with signaling pathways and proteins.
Main Results:
- DLG5 impacts cancer progression through interactions with key proteins and pathways (e.g., E-cadherin, p53, AKT, Hippo).
- DLG5 exhibits a dual role in human diseases, with varied expression patterns across different cancers.
- DLG5 is overexpressed in pancreatic adenocarcinoma but reduced in lung, liver, breast, prostate, and bladder cancers.
Conclusions:
- DLG5 plays a complex and context-dependent role in various diseases, including cancer.
- Understanding DLG5's function and dysregulation is critical for developing novel therapeutic strategies.
- Further research into DLG5 variants and their specific roles is warranted for targeted treatments.
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