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Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection
Published on: December 15, 2023
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Chronic Hepatitis C: Advances in Therapy and the Remaining Challenges
Saleh A Alqahtani1, Mark S Sulkowski2
1Liver Transplant Centre, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia; Division of Gastroenterology and Hepatology, Johns Hopkins University, Baltimore, MD, USA.
The Medical Clinics of North America
|March 31, 2023
Summary
Direct-acting antiviral agents (DAAs) offer high cure rates for Hepatitis C virus (HCV) infection. However, challenges like drug resistance, cancer development, and treating complex patient groups require further attention for widespread success.
Area of Science:
- Hepatology
- Virology
- Infectious Diseases
Background:
- Hepatitis C virus (HCV) infection is a major cause of liver cirrhosis and hepatocellular carcinoma (HCC).
- Liver transplantation is often necessary for advanced HCV-related liver disease.
- Direct-acting antiviral agents (DAAs) have revolutionized HCV treatment, achieving high sustained virological response rates.
Purpose of the Study:
- To review the impact of DAAs on HCV treatment outcomes.
- To highlight persistent clinical challenges and unresolved issues following DAA therapy.
- To emphasize the need for population-level strategies for HCV eradication.
Main Methods:
- Literature review of studies on DAA efficacy and outcomes.
- Analysis of clinical concerns including resistance and HCC development.
- Evaluation of treatment considerations for special populations.
Main Results:
- DAAs achieve sustained virological response in over 98% of patients.
- Resistant-associated substitutions and HCC post-treatment are emerging concerns.
- Unresolved issues persist for patients with chronic kidney disease and decompensated cirrhosis.
Conclusions:
- While DAAs are highly effective, challenges remain in managing resistance and preventing HCC.
- Special populations require tailored approaches for successful HCV eradication.
- Large-scale screening and treatment programs are crucial for population-level HCV elimination.
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