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Relationship of Serum Creatinine Level in Heart Failure Patients in Bangladesh
M Banu1, M M Rahaman, M R Hoque
1Dr Motahera Banu, Lecturer, Department of Biochemistry, Mymensingh Medical College (MMC), Mymensingh, Bangladesh;
Insights
Elevated serum creatinine levels were observed in heart failure (HF) patients compared to healthy individuals. This finding suggests serum creatinine may aid in managing heart failure.
Area of Science:
- Biochemistry
- Cardiology
- Clinical Medicine
Background:
- Heart failure (HF) occurs when the heart weakens and cannot pump blood effectively.
- Effective management of HF requires understanding contributing physiological factors.
- Serum creatinine is a marker of kidney function, which can be impacted by HF.
Purpose of the Study:
- To investigate the relationship between serum creatinine levels and heart failure.
- To assess the potential utility of serum creatinine in HF management.
- To compare serum creatinine levels in HF patients versus healthy controls.
Main Methods:
- A cross-sectional study was conducted involving 120 participants (60 HF patients, 60 healthy controls).
- Serum creatinine was measured using a colorimetric method.
- Statistical analysis was performed using SPSS version 21.
Main Results:
- Mean serum creatinine levels were significantly higher in HF patients (2.20±0.87 mg/dL) compared to controls (0.92±0.26 mg/dL).
- The difference in serum creatinine levels between groups was statistically highly significant (p<0.001).
Conclusions:
- Serum creatinine levels are significantly elevated in patients with heart failure.
- Serum creatinine may serve as a valuable biomarker for HF management.
- Further research is warranted to explore the clinical implications of these findings.
Abstract:
Heart failure means that the heart is unable to pump blood around the body properly. It usually happens because the heart has become too weak or stuff. In collaboration with department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh this cross-sectional study from January to December 2018 was performed in the department of Biochemistry in Mymensingh Medical College, Mymensingh, Bangladesh. The aim of this study was to explore the relationship of serum creatinine in patients with heart failure (HF) for management purpose. In this study 120 subjects were included, where 60 patients of diagnosed HF acts as case group and 60 individuals were normal healthy acts as control group. Serum creatinine was determined by colorimetric method from each sample. Statistical analysis was performed by SPSS windows package, version 21. Among the study groups the mean serum creatinine levels were 2.20±0.87mg/dl and 0.92±0.26mg/dl in case and control group respectively. Analysis showed that the mean serum creatinine level was highly significantly (p<0.001) increased in HF patients in comparison to that of control group.
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