Related Experiment Video
Updated: Aug 4, 2025
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Prediction of Coronary Artery Disease Severity by Using CHA2DS2-VASC-HSF Score in Patients with ST-Elevation
M A Rahim1, M J Uddin, J Jahan
1Dr Mohammad Abdur Rahim, MD, Department of Cardiology, National Institute of Cardiovascular Diseases (NICVD), Dhaka, Bangladesh;
Insights
The CHA₂DS₂-VASC-HSF score effectively predicts the severity of coronary artery disease (CAD) in ST-elevation myocardial infarction (STEMI) patients. A higher score indicates more severe CAD, suggesting its utility as a prognostic tool.
Area of Science:
- Cardiology
- Vascular Medicine
- Medical Informatics
Background:
- Coronary artery disease (CAD) poses a significant global health burden.
- Existing risk scores like CHADS₂ and CHA₂DS₂-VASc share risk factors with CAD development.
- The novel CHA₂DS₂-VASC-HSF score incorporates factors known to promote atherosclerosis and CAD severity.
Purpose of the Study:
- To investigate the association between the CHA₂DS₂-VASC-HSF score and the severity of CAD.
- To evaluate the CHA₂DS₂-VASC-HSF score's predictive capability in patients experiencing ST-elevation myocardial infarction (STEMI).
Main Methods:
- A cohort of 100 STEMI patients was studied over one year.
- Coronary angiography assessed CAD severity using the SYNTAX score.
- Patients were categorized based on SYNTAX score (≥23 vs. <23) and CHA₂DS₂-VASC-HSF score (≥4.0 vs. <4.0).
Main Results:
- Patients with higher CHA₂DS₂-VASC-HSF scores (≥4.0) exhibited significantly higher SYNTAX scores, indicating more severe CAD.
- A positive correlation was observed between CHA₂DS₂-VASC-HSF score and CAD severity.
- The CHA₂DS₂-VASC-HSF score demonstrated high sensitivity (84.4%) and specificity (81.9%) in identifying severe CAD.
Conclusions:
- The CHA₂DS₂-VASC-HSF score is a valuable predictor of coronary artery disease severity in STEMI patients.
- This score can aid clinicians in assessing CAD complexity and guiding treatment strategies.
Abstract:
CHADS₂ and CHA₂DS₂-VASc scores are widely used in clinical practice and include similar risk factors for the development of coronary artery disease (CAD). It is known that the factors comprising the newly defined CHA₂DS₂-VASC-HSF score promote atherosclerosis and associated with severity of CAD. Objective of the study was to find out the association of the CHA₂DS₂-VASC-HSF score with the severity of CAD in patients with ST elevation myocardial infarction (STEMI). One hundred (100) patients with STEMI were enrolled in this study after considering inclusion and exclusion criteria over a one year period from October, 2017 to September, 2018 in the Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh. Coronary angiogram was done within index hospitalization and coronary artery disease severity was assessed by SYNTAX score system. Patients were divided into two groups on the basis of SYNTAX score. Patients with SYNTAX score ≥23 assigned as Group I and SYNTAX score <23 assigned as Group II. The CHA₂DS₂-VASC-HSF score was calculated. Cut-off value of high CHA₂DS₂-VASC-HSF score was ≥4.0. In this study mean age of study population was 51.8±9.8, male patients were predominant (79.0%). Among the studied patients, highest percentage had history of smoking followed by hypertension, diabetes mellitus and family history of CAD in Group I patients. It was found that DM and family history of CAD and history of stroke/TIA were significantly higher in Group I than Group II. An increasing trend of SYNTAX score was observed according to the CHA₂DS₂-VASc-HSF score. SYNTAX score was significantly higher in CHA2DS2-VASc-HSF score ≥4 than CHA₂DS₂-VASc-HSF score <4 (26.3±6.3 vs. 12.1±7.7, p<0.001). Patients with CHA₂DS₂-VASC-HSF score ≥4 had severe coronary artery disease than CHA₂DS₂-VASC-HSF score <4 assessed by SYNTAX score with 84.4% sensitivity and 81.9% specificity (AUC:0.83, 95% CI: 0.746-0.915, p<0.001). CHA₂DS₂-VASc-HSF score was positively correlated with the severity of CAD. This score could be considered as a predictor of coronary artery disease severity.
More Related Videos
06:57Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
Published on: September 22, 2023
13:07Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:30Coronary Artery Disease I: Introduction
01:27Coronary Artery Disease V: Interprofessional Care