Related Experiment Video
Updated: Aug 4, 2025

A Human Cerebral Organoid Model of Neural Cell Transplantation
Published on: July 21, 2023
Solid Organ Transplantation for Children With Neurodevelopmental Disabilities-Ethical Considerations and a Call for
Kyla M Tolliver1, John J Parent2, Michael J Hobson3
1Division of Gastroenterology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.
Insights
This study examines organ transplantation for children with neurodevelopmental disabilities, addressing outcomes, quality of life, and ethical considerations. It highlights the need for clear transplant criteria for this vulnerable pediatric population.
Area of Science:
- Medical Ethics
- Pediatric Transplantation
- Neurodevelopmental Disabilities
Background:
- Pediatric transplant centers face challenges in organ allocation and patient selection.
- Children with neurodevelopmental disabilities represent a complex group requiring careful consideration for solid organ transplantation.
- Current transplant inclusion and exclusion criteria are not standardized for this population.
Purpose of the Study:
- To explore critical factors in organ transplantation for children with neurodevelopmental disorders.
- To examine patient outcomes and quality of life in this specific pediatric group.
- To discuss the ethical principles guiding transplant decisions for children with neurodevelopmental disabilities.
Main Methods:
- Literature review and ethical analysis.
- Exploration of existing data on pediatric solid organ transplantation.
- Discussion of quality of life metrics and patient-centered care.
Main Results:
- Significant concerns exist regarding the transplantation of children with neurodevelopmental disabilities.
- Lack of standardized criteria complicates fair evaluation and organ allocation.
- Patient outcomes and quality of life require careful, individualized assessment.
Conclusions:
- Organ transplantation for children with neurodevelopmental disorders necessitates a nuanced approach.
- Development of standardized, ethical guidelines is crucial for equitable care.
- Balancing medical benefit with ethical considerations is paramount in decision-making.
Abstract:
Pediatric transplant centers are faced with the difficult task of maximizing the benefit of organs donated for transplantation while also ensuring that all patients undergoing transplant evaluation are fairly considered for this life-saving therapy. Children with neurodevelopmental disabilities are a complex patient population that on occasion may face the need for a solid organ transplant. Several concerns exist regarding transplantation in this population, yet standard transplant inclusion and exclusion criteria do not exist. Here we explore important factors regarding organ transplantation for children with neurodevelopmental disorders, including patient outcomes, quality of life considerations, and the fundamental ethical principles underlying this complex medical decision-making.
Related Concept Videos
Kidney Transplant I: Introduction
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Psychosurgery
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Ethical Issues
Ethical Concerns in Healthcare:
Ethical Dilemmas I
Let us explore some examples to understand the potentially complex moral decisions nurses face.
Take the case of caring for minors, particularly in areas related to reproductive...
Stem Cell Culture

