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Updated: Aug 4, 2025

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Ethical Considerations of Genome Sequencing for Pediatric Patients
Michelle M Sergi1, Melissa C Keinath2, Jonathan Fanaroff3
1From theUniversity Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH; Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Cleveland Medical Center, Cleveland, OH; MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, IL.
Abstract:
Advancements in genetic testing in the healthcare setting, most recently genomic sequencing, has enhanced our ability to diagnose genetic conditions. These advances include increased accessibility and affordability of genomic technologies. With expanded use comes the potential for significant ethical challenges for clinicians, particularly considering the implications of testing a child for one condition and incidentally finding a different condition or health risk. In this focused review, we address various ethical considerations from informed consent to the rights of a child undergoing genetic testing.
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