Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

5.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Epicatechin Supplementation on Plasma Proteome Profiles in Obese Men and Women-An Exploratory Approach to Sexual Dimorphism.

Proteomics. Clinical applications·2025
Same author

Does Green Tea Ameliorate Obesity in Mice Kept at Thermoneutrality by Modulating Skeletal Muscle Metabolism?

Cell biochemistry and function·2025
Same author

Are glyphosate or glyphosate-based herbicides linked to metabolic dysfunction-associated steatotic liver disease (MASLD)? The weight of current evidence.

Environmental toxicology and pharmacology·2025
Same author

Transcriptomic implications of low herbicide concentrations in hepatic cells: Insights into the individual and combined effects of 2,4-D, glyphosate, and AMPA.

Toxicology letters·2025
Same author

No UCP1 in the kidney.

Molecular metabolism·2025
Same author

In isolated brown adipose tissue mitochondria, UCP1 is not essential for - nor involved in - the uncoupling effects of the classical uncouplers FCCP and DNP.

Biochimica et biophysica acta. Bioenergetics·2024

Related Experiment Video

Updated: Aug 4, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.7K

Green tea actions on miRNAs expression - An update.

Celso Pereira Batista Sousa-Filho1, Victoria Silva1, Anaysa Paola Bolin2

  • 1Interdisciplinary Post-graduate Program in Health Sciences, Cruzeiro do Sul University, São Paulo, Brazil.

Chemico-Biological Interactions
|April 2, 2023
PubMed
Summary

Green tea compounds may impact metabolic diseases by altering microRNA (miRNA) expression. Further research is needed to understand how these plant-derived molecules influence cellular communication and health outcomes.

Keywords:
Adipose tissueGreen teaInflammationLiverSkeletal musclemiRNA

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.4K

Related Experiment Videos

Last Updated: Aug 4, 2025

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

17.7K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Plant-derived compounds are investigated for metabolic diseases.
  • Camellia sinensis (green tea) effects are known, but mechanisms are unclear.
  • MicroRNAs (miRNAs) are key regulators in cellular pathways and disease.

Purpose of the Study:

  • To review studies on green tea compounds modulating miRNA expression.
  • To explore the role of miRNAs in green tea's beneficial effects.
  • To highlight research gaps in miRNA-mediated mechanisms of green tea.

Main Methods:

  • Literature review focusing on green tea compounds and miRNA expression.
  • Analysis of studies investigating miRNA modulation in inflammation, adipose tissue, skeletal muscle, and liver.
  • Synthesis of current evidence on miRNA involvement in green tea's health effects.

Main Results:

  • Green tea compounds may influence miRNA expression.
  • miRNAs are implicated in the cellular actions of green tea.
  • Evidence suggests miRNAs link green tea's polyphenols to health benefits.

Conclusions:

  • A significant knowledge gap exists regarding miRNA's role in green tea's health benefits.
  • miRNAs represent a promising area for investigating green tea's therapeutic potential.
  • Polyphenols may exert their effects, in part, by altering miRNA expression.