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The Auditory Ossicles01:11

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The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
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Middle Ear Muscle Reflex in Normal-Hearing Individuals with Occupational Noise Exposure.

Sahana Vasudevamurthy1, Ajith U Kumar2

  • 1Facility for Advanced Auditory Research (FAAR), Department of Audiology, All India Institute of Speech and Hearing, Mysuru, Karnataka, India.

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|April 3, 2023
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Summary
This summary is machine-generated.

Acoustic middle ear muscle reflex (MEMR) strength, not threshold, was reduced in individuals with occupational noise exposure, suggesting its potential for diagnosing cochlear synaptopathy.

Keywords:
Acoustic reflexcochlear neuropathycochlear synaptopathyhidden hearing lossmiddle ear muscle reflex

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Area of Science:

  • Audiology
  • Neuroscience
  • Occupational Health

Background:

  • Noise-induced cochlear synaptopathy is difficult to diagnose in humans.
  • Noninvasive measures are being explored for synaptopathy detection.
  • Acoustic middle ear muscle reflex (MEMR) is sensitive to noise exposure effects on auditory nerve fibers.

Purpose of the Study:

  • To investigate MEMR threshold and strength as potential indicators of cochlear synaptopathy.
  • To compare MEMR responses between noise-exposed and non-exposed individuals with normal hearing.

Main Methods:

  • Participants were divided into a control group (n=25) and a noise-exposed group (n=25).
  • Noise exposure group had occupational exposure to 85 dBA for at least 1 year.
  • MEMR threshold and strength were measured using pure tones (500 Hz, 1000 Hz) and broadband noise.

Main Results:

  • No significant difference in MEMR threshold was found between the groups.
  • MEMR strength was significantly reduced in the noise-exposed group compared to the control group.

Conclusions:

  • MEMR strength may serve as a sensitive biomarker for identifying cochlear synaptopathy.
  • Stimulus characteristics are important when using MEMR for synaptopathy assessment.