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Functional Analysis of Monkeypox and Interrelationship between Monkeypox and COVID-19 by Bioinformatic Analysis
1College of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
Genetics Research
|April 3, 2023
Summary
Monkeypox and COVID-19 share molecular pathways, including cytokine signaling and TNF signaling. This study identifies common gene expression patterns to better understand monkeypox virus infection mechanisms.
Area of Science:
- Virology
- Genomics
- Immunology
Background:
- The monkeypox outbreak presents a novel public health threat, necessitating urgent research.
- Limited studies exist on monkeypox gene expression since its emergence.
Purpose of the Study:
- To systematically analyze gene expression in monkeypox-infected cells.
- To compare functional gene expression profiles between monkeypox and COVID-19.
Main Methods:
- Transcriptome profiling of monkeypox datasets (GSE36854, GSE21001).
- Enrichment analyses (KEGG, Gene Ontology) for differentially expressed genes (DEGs).
- Protein-protein interaction network analysis and comparison with SARS-CoV-2 data.
Main Results:
- Identified 212 DEGs in monkeypox, associated with cytokine response, cell activation, and differentiation.
- KEGG analysis revealed involvement in cytokine-cytokine receptor interaction, TNF signaling, and T cell receptor signaling.
- Common functions with COVID-19 include immune system cytokine signaling, TNF signaling, and MAPK cascade regulation.
Conclusions:
- Monkeypox and COVID-19 share significant molecular pathways.
- Understanding these shared mechanisms can elucidate monkeypox pathogenesis.
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