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CDC20 Regulates the Progression of Clear Cell Renal Cell Carcinoma via the Wnt/β-Catenin Signaling Pathway

YuHu Hao1, Leizuo Zhao2, Yanning Sun1

  • 1Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China, sdu.edu.cn.

Genetics Research
|July 20, 2026
PubMed
Abstract

Insights

Cell division cycle 20 homolog (CDC20) is upregulated in clear cell renal cell carcinoma (ccRCC), correlating with poor prognosis. Targeting CDC20 may offer a new therapeutic strategy for ccRCC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Clear cell renal cell carcinoma (ccRCC) is a significant cause of cancer-related mortality.
  • The role of cell division cycle 20 homolog (CDC20) in ccRCC pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the expression levels of CDC20 in ccRCC.
  • To explore the biological functions and prognostic significance of CDC20 in ccRCC.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) database for bioinformatics analysis.
  • Performed immunohistochemistry (IHC), EDU, CCK-8, wound healing, and Transwell assays.
  • Verified findings in vivo using a nude mouse xenograft model and western blotting for mechanistic studies.

Main Results:

  • CDC20 was found to be upregulated in ccRCC, with high expression linked to poorer prognosis in kidney renal cell carcinoma (KIRC) patients.
  • Knockdown of CDC20 inhibited renal cancer cell proliferation, migration, and invasion.
  • In vivo studies demonstrated that reduced CDC20 expression suppressed tumor growth.

Conclusions:

  • High CDC20 expression in KIRC tissues suggests its potential as a therapeutic target.
  • CDC20 serves as a valuable prognostic marker for KIRC patients.
Keywords:
CDC20Wnt signaling pathwayccRCCmetastasisproliferation

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