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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease

S S Kang, P W Wong, H Y Cook

    The Journal of Clinical Investigation
    |May 1, 1986
    PubMed

    Insights

    Elevated homocysteine (Hcy) levels in the blood are linked to an increased risk of coronary artery disease (CAD). This study found significantly higher total plasma Hcy in CAD patients compared to controls, supporting a positive correlation.

    Area of Science:

    • Cardiovascular Medicine
    • Clinical Biochemistry
    • Medical Research

    Background:

    • Homocystinuria is associated with atherosclerotic changes and thromboembolism.
    • A potential correlation between blood homocysteine levels and coronary artery disease (CAD) occurrence is postulated.
    • Homocysteine exists in various forms, with protein-bound homocysteine being predominant in non-homocystinuric individuals.

    Purpose of the Study:

    • To investigate the correlation between total plasma homocysteine levels and the presence of coronary artery disease.
    • To determine if elevated homocysteine is a significant risk factor for CAD.

    Main Methods:

    • Determined protein-bound homocysteine in stored plasma, reflecting total plasma homocysteine.
    • Analyzed plasma samples from 241 patients diagnosed with coronary artery disease (173 males, 68 females) and control groups.
    • Statistical analysis was performed to compare homocysteine levels between patients and controls.

    Main Results:

    • Mean total plasma homocysteine was significantly higher in male patients (5.41 +/- 1.62 nmol/ml) compared to male controls (4.37 +/- 1.09 nmol/ml).
    • Mean total plasma homocysteine was significantly higher in female patients (5.66 +/- 1.93 nmol/ml) compared to female controls (4.16 +/- 1.62 nmol/ml).
    • The observed differences in homocysteine levels between CAD patients and controls were statistically significant (P < 0.0005).

    Conclusions:

    • Elevated total plasma homocysteine levels are significantly associated with coronary artery disease.
    • The findings support the hypothesis that homocysteine is a risk factor for the development of CAD.
    • Further research into homocysteine-lowering therapies for CAD prevention may be warranted.

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