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Zwitterionic peptides: Tunable next-generation stealth nanoparticle modifications.

Clyde Overby1,2, Soomin Park3, Austin Summers4

  • 1Department of Biomedical Engineering University of Rochester, Rochester, NY, USA.

Bioactive Materials
|April 3, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed zwitterionic peptides (ZIPs) to control protein adsorption on nanoparticles (NPs). The sequence and charge order of ZIPs, not their composition, dictate the protein corona, enabling tunable NP properties.

Keywords:
Cellular uptakeNanoparticlesPeptide designProtein coronaSurface functionalization

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Surface Chemistry

Background:

  • Protein adsorption onto nanoparticles forms a protein corona, influencing nanoparticle behavior in vivo.
  • Current surface modifications can control protein quantity but not identity on nanoparticle surfaces.
  • Understanding and controlling the protein corona is crucial for optimizing nanoparticle applications.

Purpose of the Study:

  • To develop novel zwitterionic peptides (ZIPs) for nanoparticle (NP) surface functionalization.
  • To investigate the ability of ZIPs to control protein adsorption profiles and the resulting protein corona.
  • To establish a method for tuning nanoparticle-protein interactions via surface chemistry.

Main Methods:

  • Synthesis and characterization of diverse zwitterionic peptides (ZIPs).
  • Conjugation of ZIPs to nanoparticles (NPs).
  • Serum exposure of ZIP-conjugated NPs followed by proteomics analysis of the adsorbed proteins.

Main Results:

  • ZIP surface functionalization allows for specific and controllable protein adsorption profiles.
  • The sequence and charge motif of ZIPs, rather than their exact composition, determine the protein adsorption profile.
  • This control over the protein corona can influence nanoparticle pharmacokinetics and biodistribution.

Conclusions:

  • Zwitterionic peptides (ZIPs) offer a tunable platform for engineering nanoparticle-protein interactions.
  • ZIP charge motif engineering provides a strategy to precisely control the protein corona composition.
  • This approach has implications for enhancing nanoparticle specificity, improving pharmacokinetics, and potentially mitigating immune responses.