Related Experiment Video
Updated: Aug 4, 2025

08:22
Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
4.2K
Inner Retinal Morphology and Visual Outcomes in Idiopathic Epiretinal Membrane Surgery: A Retrospective Optical
Ioannis S Dimopoulos1, Michael Dollin1
1University of Ottawa Eye Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Journal of Vitreoretinal Diseases
|April 3, 2023
Summary
Disorganization of the retinal inner layers (DRIL) predicts poor visual outcomes after epiretinal membrane (ERM) surgery. Severe DRIL is linked to worse vision and less improvement, highlighting its role in predicting long-term results.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Surgical Outcomes
Background:
- Epiretinal membrane (ERM) is a common condition in patients over 50.
- Disorganization of the retinal inner layers (DRIL) is a newly identified factor impacting visual acuity (VA).
Purpose of the Study:
- To assess the correlation between preoperative DRIL and visual outcomes following ERM surgery.
- To determine if DRIL can predict long-term visual results after ERM treatment.
Main Methods:
- Retrospective review of 81 pseudophakic patients undergoing idiopathic ERM surgery.
- Correlation of preoperative optical coherence tomography (OCT) findings of DRIL with VA at baseline and 3, 6 months post-surgery.
- DRIL severity categorized based on extent within the central 2-mm region.
Main Results:
- Severe DRIL was present in 41% of patients, associated with worse baseline VA (P < .001).
- Both baseline VA and DRIL status predicted postoperative VA (P < .001).
- Severe DRIL correlated with less VA improvement at 6 months (-0.14 logMAR vs. -0.23 logMAR).
Conclusions:
- Severe preoperative DRIL is linked to poorer baseline VA in ERM patients.
- DRIL is a strong predictor of reduced visual improvement and long-term poor outcomes after ERM surgery.

