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Reticular corneal epithelial edema with topical netarsudil
Dipali P Parmar1, Pradnya K Bhole1, Pawan V Garde1
1Department of Ophthalmology, M and J Institute of Ophthalmology (Government Eye Hospital), B. J. Medical College, Ahmedabad, Gujarat, India.
Oman Journal of Ophthalmology
|April 3, 2023
Summary
Rho-associated kinase (ROCK) inhibitors, like netarsudil, can cause reticular epithelial edema (REE) in some patients. This side effect typically resolves upon discontinuation of the ROCK inhibitor therapy.
Area of Science:
- Ophthalmology
- Corneal Disease
- Pharmacology
Background:
- Rho-associated kinase (ROCK) inhibitors are used for corneal endothelial dysfunction, generally with few side effects.
- Netarsudil 0.02% is a ROCK inhibitor used in ophthalmic treatments.
Observation:
- Reticular epithelial edema (REE) was observed in four patients undergoing treatment with netarsudil.
- These cases involved corneal transplants (3) and post-cataract extraction (1).
Findings:
- REE developed variably in all observed cases.
- Discontinuation of netarsudil led to REE clearance in three patients.
- One patient continued netarsudil with REE not affecting the visual axis.
Implications:
- ROCK inhibitor therapy, specifically netarsudil, may induce REE in certain ophthalmic conditions.
- Monitoring for and managing REE is important during ROCK inhibitor treatment.
- Partial stromal edema clearance suggests potential benefits alongside observed side effects.
