Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

Hypertension II: Pathophysiology

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deviated Uvula Resulting From Herpes Zoster Infection: A Case Report.

Cureus·2026

Same author

Multiple Ganglion Cysts of the Wrist and Leg in a 70-Year-Old Female: A Case Report.

Cureus·2026

Same author

Calcifying odontogenic cyst of the gingiva: Diagnostic challenges in a central lesion presenting as a peripheral reactive swelling.

Journal of Indian Society of Periodontology·2025

Same author

Laser-Assisted Gingivectomy in Amlodipine-Induced Gingival Enlargement: A Case Report.

Cureus·2025

Same author

Mandibular Bony Exostoses or Hyperostosis: A Case Report.

Cureus·2024

Same author

Professor Dr. Bangalore Krishnaswamy Venkataraman (1923-2018): An Icon and Pioneer of Oral Medicine in India.

Cureus·2024

Search research articles

Related Experiment Video

Updated: Aug 4, 2025

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

Amlodipine-Induced Gingival Hypertrophy: A Case Report.

Karthik Rajaram Mohan¹, Saramma Mathew Fenn¹, Ravikumar Pethagounder Thangavelu¹

¹Oral Medicine and Radiology, Vinayaka Mission's Sankarachariyar Dental College, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, IND.

|April 3, 2023

Summary

Drug-induced gingival hypertrophy, like that from amlodipine, can affect susceptible individuals. This condition impacts speech, eating, oral hygiene, and appearance, with a multifactorial cause.

Keywords:

amlodipine antihypertensive drugs gingival hypertrophy gingivectomy oral health care

More Related Videos

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Related Experiment Videos

Last Updated: Aug 4, 2025

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

Area of Science:

Pharmacology
Oral Medicine
Genetics

Background:

Gingival hypertrophy is a known side effect of certain medications, including calcium channel blockers like amlodipine.
The exact mechanisms are not fully understood but are thought to be multifactorial, involving genetic predisposition.
This condition can lead to significant functional and aesthetic issues.

Observation:

A case study of a 54-year-old woman presenting with drug-induced gingival hypertrophy.
The patient had been taking amlodipine 5 mg twice daily for four years as an antihypertensive medication.
The hypertrophy developed over the course of her long-term amlodipine treatment.

Findings:

Amlodipine, a commonly prescribed antihypertensive, can induce gingival overgrowth in susceptible individuals.
The condition presents with significant enlargement of the gingiva, affecting oral health.
A multifactorial etiology is proposed, highlighting the interplay between medication and host factors.

Implications:

Understanding the link between amlodipine and gingival hypertrophy is crucial for clinicians.
Early recognition and management can mitigate functional and aesthetic consequences.
Further research into the multifactorial mechanisms may reveal targeted therapeutic strategies.